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Hartskeerl, R.A.
Hoofd Leptospirose Referentielaboratorium
KIT Biomedical Research
Leptospirosis research and diagnosis
Publicaties
- Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world (2011)
- Potent Innate Immune Response to Pathogenic Leptospira in Human Whole Blood (2011)
- Establishment of valid laboratory case definition for human leptospirosis. (2011)
- Molecular approaches in the detection and characterization of Leptospira. (2011)
- Monitoring Leptospira Strain Collections: The Need for Quality Control (2010)
- Bioinformatics Describes Novel Loci for High Resolution Discrimination of Leptospira Isolates (2010)
- Challenges in determining the pathogenicity status of Leptospira isolates with phenotypic methods: The need for a polyvalent approach (2010)
- Estimating the burden of human leptospirosis (2010)
- Genetic Affinities within a Large Global Collection of Pathogenic Leptospira: Implications for Strain Identification and Molecular Epidemiology (2010)
- Mutations affecting Leptospira interrogans lipopolysaccharide attenuate virulence (2010)
- A simple and rapid molecular method for Leptospira species identification (2010)
- Evaluation of the Use of Selective PCR Amplification of LPS Biosynthesis Genes for Molecular Typing of Leptospira at the Serovar Level (2010)
- First Isolation and Direct Evidence for the Existence of Large Small-Mammal Reservoirs of Leptospira sp. in Madagascar (2010)
- Leptospirose (ziekte van Weil) bij de hond: een risico voor de mens? (2009)
- Long pentraxin PTX3 is associated with mortality and disease severity in severe Leptospirosis (2009)
- Soluble ST2 Levels Are Associated with Bleeding in Patients with Severe Leptospirosis (2009)
- Development and Validation of a Real-Time PCR for Detection of Pathogenic Leptospira Species in Clinical Materials (2009)
- Leptospirose in 2006: bijna de helft werd in Nederland opgelopen (2008)
- Seroepidemiology and serological follow-up of anti-leptospiral IgG in children in Southern Vietnam (2008)
- Meer leptospirose in 2007 (2008)
- Leptospirose: rattenziekte of toch niet? (2008)
- ISOLATION OF LEPTOSPIRA SEROVARS CANICOLA AND COPENHAGENI FROM CATTLE URINE IN THE STATE OF PARANÁ, BRAZIL (2008)
- Arenal, a new Leptospira serovar of serogroup Javanica, isolated from a patient in Costa Rica (2008)
- Conservation of the S10-spc-alpha locus within otherwise highly plastic genomes provides phylogenetic insight into the Genus Leptospira. (2008)
- Leptospirose bij honden: een risico voor de mens? (2008)
- Leptospirosis # 164. Spirochetal Diseases, Section 9. Infectious Diseases Part 7 (2008)
- Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil (2007)
- Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis. (2007)
- Twee postmortaal vastgestelde gevallen van leptospirose bij de hond. [Post-mortem diagnosis of leptospirosis in two dogs.] (2007)
- Field rats form a major infection source of leptospirosis in and around Madurai, India. (2007)
- Field rats form a major infection source of leptospirosis in and around Madurai, India (2007)
- What role do coagulation disorders play in the pathogenesis of leptospirosis? (2007)
- Multilocus sequence typing method for identification and genotypic classification of pathogenic Leptospira species. (2006)
- Limited Diagnostic Capacities of Two Commercial Assays for the Detection of Leptospira Immunoglobulin M Antibodies in Laos (2006)
- An outbreak of leptospirosis in seals (Phoca vitulina) in captivity (2006)
- PCR detection of Leptospira DNA in rodents and insectivores from Tanzania (2006)
- Leptospirose in 2005: veel infecties tijdens vakantie in de tropen. (2006)
- New Leptospira serovar Sokoine of serogroup Icterohaemorrhagiae from cattle in Tanzania. (2006)
- Buenos Aires, a new Leptospira serovar of serogroup Djasiman, isolated from an aborted dog fetus in Argentina (2005)
- Leptospirosis in 2003 and 2004: notable differences. [Leptospirose in 2003 en 2004: opmerkelijke verschillen.] (2005)
- Interactions of Leptospira with Environmental Bacteria from Surface Water (2005)
- Impact of proficiency testing on results of the microscopic agglutination test for the diagnosis of leptospirosis. (2004)
- A unique strain of Leptospira isolated from a patient with pulmonary haemorrhages in the Andaman Islands: a proposal of serovar portblairi of serogroup Sehgali (2004)
- Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis. (2004)
- Serological and molecular characterization of leptospira serovar Kenya from captive African giant pouched rats (Cricetomys gambianus) from Morogoro Tanzania. (2004)
- Leptospira spp. (2004)
- Classification of leptospira from the eyes of horses suffering from recurrent uveitis. (2004)
- Leptospirosis with Pulmonary Hemorrhage, Caused by a New Strain of Serovar Lai: Langkawi (2004)
- Characterisation of Leptospira isolates from captive giant African pouched rats, Cricetomys gambianus (2003)
- Leptospira interrogans serovar Valbuzzi: a cause of severe pulmonary haemorrhages in the Andaman Islands. (2003)
- Leptospirosis in 2002; No important differences with 2001. [Leptospirosis in 2002; Geen belangrijke verschillen met 2001.] (2003)
- Leptospirosis: an underestimated infection disease. [Leptospirose: een onderschatte infectieziekte.] (2003)
- Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans. (2003)
- Minutes of International Scientific Workshop 'Leptospirosis 2001', 17-18 May 2001 in Havana, Cuba (2002)
- Import van leptospirose in 2001 afgenomen. (2002)
- Leptospirosis, water sports, and chemoprophylaxis. (2002)
- Reunion Cientifica Internacional 'Lesptospirosis 2001' (2002)
- Isolation of Leptospira santorosai, serovar guaricura from buffaloes (Bubalus Bubalis) in Vale do Ribeira, Sao Paulo, Brazil. (2001)
- Latex based, rapid and easy assay for human leptospirosis in a single test format. (2001)
- Lai-like Leptospira from the Andaman Islands. (2000)
- International multi-centre evaluation of a dipstick assay for human leptospirosis. (2000)
- Characterization of the Leptospira interrogans S-10-spc-alfa operon (2000)
- Simple latex agglutination assay for rapid serodiagnosis of human leptospirosis (2000)
- International multicenter evaluation of the clinical utility of a dipstick assay for detection of Leptospira-specific imminuglobulin M antibodies in human serum specimens (1999)
- ELISA for the quantification of leptospiral antigens in canine vaccine (1999)
- Leptospirose in Nederland 1991-1995 (1998)
- Leptospirose veroorzaakt door Pomona (1998)
- LEPTO dipstick, a dipstick assay for detection of Leptospira-specific immunoglobulin M antibodies in human sera. (1997)
- Diagnosis of infections caused by Enterocytozoon bieneusi and Encephalitozoon intestinalis using polymerase chain reaction in stool specimens. (1997)
- Detection and species identification of intestinal microsporidia by polymerase chain reaction in duodenal biopsies from human immunodeficiency virus-infected patients. (1996)
- Characterization of Encephalitozoon (Septata) intestinalis isolates cultured from nasal mucosa and bronchoalveolar lavage fluids of two AIDS patients. (1996)
- Leptospirosis in wild animals. (1996)
- Use of nondenaturing silver-stained polyacrylamide gel analysis of polymerase chain reaction amplification products for the differential diagnosis of Leptospira interrogans infection. (1995)
- A 46 kDa integral membrane protein from Mycobacterium leprae resembles a number of bacterial and mammalian membrane transport proteins. (1995)
- Evaluation of the polymerase chain reaction for early diagnosis of leptospirosis. (1995)
- Genetic and immunological characterization of the microsporidian Septata intestinalis Cali, Kotler and Orenstein (1993: reclassification to Encephalitozoon intestinalis. (1995)
- PCR amplification reaction in parasitology (1995)
- Detection of leptospires in urine by PCR for early diagnosis of leptospirosis. (1994)
Projecten
- WHO/FAO Collaborating Centre for Reference and Research on Leptospirosis
- OIE Reference Laboratory for Leptospirosis
- National Reference Laboratory for Leptospiroses
- Assessment of magnitude and importance of vector-borne diseases in Europe (V-Borne)
- A comprehensive multidisciplinary study on the epidemiology of the haemorrhagic fevers, leptospirosis and dengue in Central America
- Prevention of sanitary risks linked to rodents at the rural/peri-urban interface. (RATZOOMAN)
- Haemorrhagic fevers in Indonesia
- A pilot study to establish leptospiral etiology of uveitis
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