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Tuberculosis
Tuberculosis
Tuberculosis is a disease of increasing importance. Patients spread the disease by coughing which produces
aerosols containing the M. bacteria. Persons that have close
contact with these patients may inhale these micro droplets and thus become infected. The mycobacteria multiply in the lung and cause disease in
around 10% of the infected people. For HIV positive persons the risk of developing active TB, if they are infected, is much greater. Annually over
three million people die from TB and up to one third of the world population is infected with Mycobacterium tuberculosis. Mortality is highest in the tropics, where over three-quarters of cases occur.
It is estimated that the incidence of tuberculosis worldwide and the number of cases attributable to co-existing human immune-deficiency virus (HIV) infection will increase substantially during the next decade. Most of this burden occurs among the low-income countries of the world, particularly those in South East Asia and sub-Saharan Africa.
Diagnosis
Microscopic examination of sputum allows the mycobacteria to be observed and is an important marker for infectiousness. When done properly, approximately 60-70% of all adults with pulmonary tuberculosis can be identified by microscopy. In practice however this proportion is around 40-60% at best. In the short tem improvements in microscopy are valuable but the real challenge is to develop a simple and cheap test- with at least as good detection limit as direct microscopy; 104 bacteria/ml- that can reduce the workload of the laboratory personnel.
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