Discordant Treatment Responses to Combination Antiretroviral Therapy in Rwanda: A Prospective Cohort Study


M.I. Bakker, et al.

The aim of combination antiretroviral therapy (cART) is to suppress plasma human immunodeficiency virus (HIV) viral load (VL) to undetectable levels. The usual median time to achieve full viral suppression is about 100 days. Most HIV patients, both in high-income and in resource-poor countries, also display an immunological response to treatment, measured as an increase in CD4 count. In 14–25% of patients CD4 count does not rise substantially
despite successful viral suppression. This phenomenon has been referred to as an immunological discordant treatment response