The INFIR Cohort Study: assessment of sensory and motor neuropathy in leprosy at baseline


W.H. van Brakel, P. G. Nicholls, L. Das, P. Barkataki, P. Maddali, D. Lockwood, E. Wilder-Smith

Leprosy is known for the neuropathy it causes. Different methods have been used to detect leprosy-related nerve function impairment (NFI).More sophisticated methods for assessing nerve function such as vibrometry, laser Doppler flowmetry and thermal threshold testing have been shown to detect different modalities of leprous neuropathy. However, it is not known which of these testing methods would detect the neuropathy earliest. To determine this, the methods needed to be compared in a carefully planned prospective study.